Ion Channel Piezo1 Induces Ferroptosis of Trabecular …

Purpose: This study aims to elucidate the role of Piezo1, a mechanosensitive molecule, in trabecular meshwork cells (TMCs) in the context of Primary Open Angle Glaucoma (POAG), a leading cause of irreversible visual impairment. Dysfunction of the trabecular meshwork (TM) is a key factor in the elevated intraocular pressure (IOP) observed in POAG, …

Aqueous outflow

Increased resistance in the trabecular meshwork (TM), a filter-like structure essential to regulate AH outflow, may result in the impaired outflow. Flow through the 360° circumference of TM structures may be non-uniform, divided into high and low flow regions, termed as segmental. After flowing through the TM, AH enters Schlemm's canal (SC ...

Improving Stem Cell Delivery to the Trabecular Meshwork …

The trabecular meshwork (TM), the tissue that primarily regulates intraocular pressure, is known to have reduced cellularity in glaucoma. Thus, stem cells, if properly delivered to the TM, may offer a novel therapeutic option for intraocular pressure control in glaucoma patients. For this purpose, targeted delivery of stem cells to the TM is ...

Differences in Trabecular Bone, Cortical Shell, and Endplate

Trabecular microstructure for all the lumbar vertebral bodies was also analyzed using high-resolution micro-CT. Although micro-CT has been previously used to evaluate lumbar trabecular microstructure, 28, 29 there has not been a study to compare trabecular microstructure between different lumbar vertebral levels. Interestingly, we observed that ...

The Trabecular Meshwork: A Basic Review of Form and …

IOP is regulated primarily by controlled adjustments of the outflow resistance which resides in the trabecular meshwork (TM) [12,13]. Since the eye is a single hydraulic unit, pressure everywhere within the eye is uniform and IOP elevations impact the optic nerve directly, since it is most vulnerable to pressure.

Second-Generation Trabecular Micro-Bypass Stents as …

Introduction: To evaluate long-term outcomes following stand-alone implantation of two second-generation trabecular micro-bypass stents (iStent inject ®, Glaukos Corp., San Clemente, CA, USA) in eyes with predominantly primary open-angle glaucoma (POAG) and considerable preoperative disease burden. Methods: Eyes with POAG, pseudoexfoliative glaucoma (PXG), …

Three-dimensional radiological anatomy of condyle trabecular …

Objectives: Three-dimensional radiological anatomic characteristics of condyle trabeculae was obtained quantitatively based on a volume-of-interest (VOI) analysis. Methods: Nine human mandibular condyle specimens were scanned by micro-computed tomography (micro-CT). A total of 34 VOIs were selected from each condyle specimen, which were divided …

Shear strength and toughness of trabecular bone are more …

Bovine trabecular bone has almost no in vivo microdamage burden (Wang et al. 2005), which avoids the possibility of confounding effects of pre-existing damage and decreases the variability of mechanical properties in comparison to human bone. Unfortunately, the architectural variability of bovine bone is relatively small, thereby limiting the ...

Trabecular Meshwork Bypass by Stent

Introduction Prevalence and Impact. Glaucoma is the second leading cause of blindness in the world. Its current worldwide prevalence in the population aged 40-80 years old is estimated to be 3.54% with the highest incidence in the African and Asian racial groups. Glaucoma is projected to affect 76 million people by 2020 and 111.8 Million in 2040.

Isolated acetabular revision with modular trabecular …

Objectives: To evaluate the role of isolated acetabular revision with modular trabecular titanium implants using simple extraction and reinsertion of femoral monoblock cemented stem (tap-out tap-in technique). Backround: In the past years, we face the burden of revising hip arthroplasties in predominantly elderly population. Methods: Single institution retrospective analysis of 17 …

Trabecul

Trabecule (lat. trabecula) reprezintă prelungiri interne ale tunicii albuginea care formează pereți conjunctivi ce compartimentează țesutul erectil al penisului, clitorisului și bulbului vestibular în camere cavernoase. [1] Aceste formațiuni reprezintă elementele interne ale corpurilor cavernoase și spongioase la bărbat și femeie. Trabeculele sunt alcătuite din țesut conjunctiv ...

Coarse trabecular pattern in bone (differentials)

Coarse trabecular bones can result from a number of causes 1,2: Paget disease (bone) osteoporosis; osteomalacia; rickets; hemaglobinopathies, e.g. thalassemia, chronic iron deficiency anemia 3; Gaucher's disease; hyperparathyroidism; See also. coarse trabecular pattern in bone (mnemonic)